Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases
Abstract The aim is to investigate the evidence for shared genetic architecture between each of Pendant asthma, allergic rhinitis and eczema with gastro-esophageal reflux disease (GERD).Structural equation models (SEM) and polygenic risk score (PRS) analyses are applied to three Swedish twin cohorts (n = 46,582) and reveal a modest genetic correlat